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KMID : 0191120090240061170
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Journal of Korean Medical Science
2009 Volume.24 No. 6 p.1170 ~ p.1176
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The Effect of Cyclooxygenase-2 Expression on Tumor Volume Response in Patients Treated with Radiotherapy for Uterine Cervical Cancer
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Kang Min-Kyu
Park Won
Choi Yoon-La
Cho Eun-Yoon
Ahn Geung-hwan
Nam Hee-Rim
Huh Seung-Jae
Ahn Yong-Chan
Lim Do-Hoon
Oh Dong-Ryul
Bae Duk-Soo
Kim Byoung-Gie
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Abstract
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We investigated the correlation between Cyclooxygenase-2 (COX-2) expression and the tumor response in patients with cervical cancer that were treated with curative radiotherapy (RT). Fifty-seven patients with squamous cell carcinoma were treated with concurrent radiochemotherapy (CRCT, n=29) or RT alone (n=28). The response of each patient was evaluated by three serial Magnetic Resonance Imaging examinations: before the start of RT, at four weeks after the start of RT (mid-RT) and at four weeks after the completion of RT (post-RT). Forty-three patients had positive COX-2 expression. The COX-2 negative patients achieved a higher rate of complete response (CR) at mid-RT than did the COX-2 positive patients (28.6% vs. 7.0%, P=0.054), but not at post-RT (64.3% vs. 69.8%). The initial tumor volume was a significant predictor of CR at mid-RT (P=0.003) and post-RT (P=0.004). The multivariate analysis showed that the initial tumor volume (at mid-RT and post-RT) and CRCT (at post-RT) were significant predictors of CR; however, the COX-2 expression was not. In conclusion, the COX-2 expression status has no significant correlation with the tumor response. Further studies on the changes in COX-2 expression levels during RT may be helpful for determination of its role in the tumor response to treatment and patient prognosis.
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KEYWORD
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Uterine Cervical Neoplasms, Cyclooxygenase 2, Radiotherapy, Tumor Burden, Tumor Response
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